Research on Repressing Allergen Cry j 1 Released from Japanese Cedar Pollen Using Todomatsu Oil

Japanese cedar (JC, Cryptomeria japonica) pollen allergens are the primary cause of JC pollinosis, a widespread seasonal allergic disorder and significant public health issue in Japan. Nevertheless, rare information on repressing released from is available. This study aims to validate repression allergen Cry j 1 (the dominant that triggers pollinosis) using todomatsu oil produced Abies sachalinensis waste, through surface plasmon resonance (SPR) experiments, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), blind docking simulation. The findings revealed reduces antibody reactivity content by 85.96% 42.12%, respectively. modeling suggested alkyl hydrophobic forces, pi–sigma bonding, hydrogen bonding principal motivating forces for components dock with 1. More than 50% amino-acid residues docked each component (except α-pinene) hydrophobic. Furthermore, components, especially β-maaliene, exhibited potent Consequently, oil, due its inexpensive, available, convenient, ecologically beneficial nature, viable measure repress